EMI-TB Eliciting Mucosal Immunity in Tuberculosis

Project ref.: 643558
Funding: H2020-PHC-2014-single-stage_RTD
PI: Dr. África González-Fernández
Duration: 01/01/2015 – 31/12/2018

Coordinator: Rajko Reilik. St George´s University of London
Responsible researcher: África González-Fernández. WP3 Heading.

Total funds granted € 7,993,667 (support to the Immunology Group: € 670,000)

Working group:

Dr. Luis Anibarro
Dra. Elina Garet
Dra. Ana Igea
Olivia Estévez
Amparo Martínez
Dra. Silvia Lorenzo

The Immunology group participates in the EMI-TB project as the leader of Work Package 3 “Mechanisms and correlates of protective immunity in animals and humans”.

As part of the WP3 we are working in collaboration with the Hospital Provincial of Pontevedra, Spain and the Instituto Nacional de Saúde (INS) of Maputo, Mozambique, to recruit a cohort of pulmonary TB patients and their contacts. This study is focused on the search of new markers of the disease and/or protection to the infection using different techniques such as transcriptomics, proteomics and characterization of cell populations by flow cytometry.

This WP is also involved in the identification of correlates of protection in mice vaccinated with new prototypes of vaccine against the TB infection. Here the main objective is the identification of the metabolic pathways and cell populations involved in the protective response generated by the vaccines in the animal model by cell cytometry and transcriptomic analysis among others.

Associated research lines: , , .