Latest Research Outputs

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Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization

Frontiers in Immunology

Our PhD student Amparo Martínez has published her first scientific article as lead author in the international journal “Frontiers in Immunology” in collaboration with relevant groups from the universities of Minho, Stockholm and London. The study analyzes the phenotypic and transcriptomic profile in lung driven by a novel nanoparticle-based vaccine against Tuberculosis. The boosting mucosal vaccine Nano-FP1, combined to BCG priming, conferred enhanced protection in mice challenged with low-dose Mtb at short term, correlated to an increase in resident memory CD4 and CD8 T cells. This study also describes the changes in the immune profile at different time-points, highlighting the most relevant pathways involved in the process. The work is framed within the European project EU Horizon2020: “Eliciting Mucosal Immunity in Tuberculosis” (EMI-TB).

 

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Genomic analysis of a second rainbow trout line (Arlee) leads to an extended description of the IGH VDJ gene repertoire

Developmental & Comparative Immunology

This study developed by Dr Susana Magadán in collaboration with researchers from France and EEUU, confirms the validity of salmonid IGHV subgroups, and extended the description of the rainbow trout IGH gene repertoire with novel sequences, while keeping nomenclature continuity. This work provides an important resource for annotation of high-throughput Ab repertoire sequencing data.

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PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis

Materials Science and Engineering: C

Two members from the Immunology Group, Dr Rosana Simón and Prof África González, have contributed to this recent paper published in collaboration with the the 3B’s Research Group (University of Minho).

Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein the study aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF α antibodies (Abs) to provide anti-inflammatory properties.

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