In our group we have worked on different projects for the development of new vaccines in order to characterize the immune response produced by them and help to identify new vaccine candidates.
Our work has been performed in collaboration with other groups with great expertise in the production of different formulations where we test the immunological effects of the prototypes both in vitro and in vivo.
We have worked on the design of vaccines aimed to treat or prevent different diseases such as Tuberculosis, Type I Diabetes, Multiple Sclerosis, Urine Tract Infection by E. coli. Our efforts in the vaccine design were focused on comparing different formulations, vaccine doses and administration routes (intranasal, intramuscular, subcutaneous, etc.) to obtain the best protection possible.
Many of the prototypes tested in our group are Nanovaccines based on nanotechnology (Nanomedicine research line), where we also have performed different nanotoxicity studies to study the potential harm this prototypes may have on the biological systems.
We also collaborate with different groups to determine novel peptide candidates for further design and development of new peptide-based vaccines for one of the most frequent causes of food allergies: fish and their parasites. To achieve this we are using new approaches like Advanced Proteomics and Systems Biology to characterize the fish and parasite allergens.